| Pair Name | Tanshinone IIA, Anti-mouse PD-1 | ||
| Phytochemical Name | Tanshinone IIA (PubChem CID: 164676 ) | ||
| Anticancer drug Name | Anti-mouse PD-1 (PubChem CID: / ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Tanshinone IIA, Anti-mouse PD-1 | |||
| Disease Info | [ICD-11: 2C12] | Hepatocellular carcinoma | Investigative | |
| Biological Phenomena | Induction-->Immunomodulatory | |||
| Gene Regulation | Down-regulation | Expression | ADGRL4 | hsa64123 |
| Up-regulation | Expression | CLDN5 | hsa7122 | |
| Down-regulation | Expression | JAK1 | hsa3716 | |
| Down-regulation | Expression | JAK2 | hsa3717 | |
| Up-regulation | Expression | OCLN | hsa100506658 | |
| Up-regulation | Expression | TJP1 | hsa7082 | |
| In Vitro Model | Jurkat | Childhood T acute lymphoblastic leukemia | Homo sapiens (Human) | CVCL_0065 |
| bEnd.3 | Healthy | Mus musculus (Mouse) | CVCL_0170 | |
| Hep-G2 | Hepatoblastoma | Homo sapiens (Human) | CVCL_0027 | |
| CTLL-2 | Healthy | Mus musculus (Mouse) | CVCL_0227 | |
| Result | This study reveals a new mechanism between TSA and ELTD1 for vascular normalization, suggesting that therapeutic or pharmacological intervention with ELTD1 may enhance the efficacy of PD-1 inhibitors in HCC. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Tanshinone IIA normalized hepatocellular carcinoma vessels and enhanced PD-1 inhibitor efficacy by inhibiting ELTD1. Phytomedicine. 2024 Jan;123:155191. doi: 10.1016/j.phymed.2023.155191. | Click |
